{"Abbreviation":"EV","Aliases":["Estradiol 17-valerate","Estradiol valerianate","Estraval","Neofollin","Femogex","Oestradiol valerate","Atladiol","Climaval","Deladiol","Duratrad","Estate","Dura-estradiol","Exten strone","Depo estro med","Repo-Estra","Delestrogen 4X","Estraval PA","Estraval 2X","Estroval-10","Pelanin","Depo-Estro-Med","Cyclocur","Femogen-L.A.","Gynokadin","Merimono"],"CAS":"979-32-8","ChEBI":"CHEBI:31561","ChEMBL":"CHEMBL1511","ChemicalClasses":[],"Chirality":"absolute","Drug Classes":"Breast Feeding; Lactation; Milk, Human; Estrogens; Hormones","Drug Indication":"Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only).   Estradiol valerate is also available in combination with [DB09123] as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding.","DurationOfAction":"Intramuscular injection injection:• 5\u0026nbsp;mg: 7 – 8\u0026nbsp;days• 10\u0026nbsp;mg: 10 – 14\u0026nbsp;days\u003ca href='#cite_note-3'\u003e\u003csup\u003e[3]\u003c/sup\u003e\u003c/a\u003e• 40\u0026nbsp;mg: 2 – 3\u0026nbsp;weeks• 100\u0026nbsp;mg: 3 – 4\u0026nbsp;weeks","EINECS":"213-559-2","EliminationHalfLife":"Oral: 12 – 20 hours (as estradiol)Intramuscular injection injection: 3.5 (1.2 – 7.2) days","Esters":[],"European Community (EC) Number":"213-559-2","FDA Pharmacological Classification":"ESTRADIOL VALERATE","Formating":[],"HMDB ID":"HMDB0303648","HeavyAtomCount":26,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Estrogens; Hormones","IUPACName":"[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate","InChI":"InChI=1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1","InChIKey":"RSEPBGGWRJCQGY-RBRWEJTLSA-N","MeSH Pharmacological Classification":"Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)","MolecularFormula":"C\u003csub\u003e23\u003c/sub\u003eH\u003csub\u003e32\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"356.5 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Estrogen mediates its effects across the body through potent agonism of the Estrogen Receptor (ER), which is located in various tissues including in the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain. Estradiol binds to both subtypes of the Estrogen Receptor: Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). Estradiol also acts as a potent agonist of G Protein-coupled Estrogen Receptor (GPER), which has recently been recognized as a major mediator of estradiol's rapid cellular effects.","PubChemId":13791,"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Estradiol_valerate","Name":"Estradiol valerate","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q5401768","Name":"Estradiol valerate","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB13956","Name":"Estradiol valerate","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/13791","Name":"Estradiol valerate","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1511","Name":"Estradiol valerate","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31561","Name":"Estradiol valerate","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=979-32-8","Name":"Estradiol valerate","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0303648","Name":"Estradiol valerate","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01413","Name":"Estradiol valerate","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/OKG364O896","Name":"Estradiol valerate","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023004","Name":"Estradiol valerate","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 13791, Estradiol valerate. Accessed July 7, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/13791\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/13791\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Estradiol valerate. UNII: OKG364O896. Global Substance Registration System. Accessed July 7, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/OKG364O896\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/OKG364O896\u003c/a\u003e","Labhart A. Clinical Endocrinology: Theory and Practice. Springer Science \u0026 Business Media. December 6, 2012. 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